<![CDATA[According to the  multidmensional economic crisis  that impact on  increasing  drug  prices,  especially prices of patented drugs /  trademark, these  condition  affect  to  the  failure in fulfill  of public  health  due  to  decreasing  of purchase power. To cope these conditions required participation of the pharmaceutical industry  especially in  the manufacture  to develop  and  socialize affordable drugs by all segments of civil society.This project aims to reduce the unit cost of products and that will directly affect the COGS product. Performed incrementally by selecting several  products  that provide the main  value of PT. AAA. To analyze the  causes and   solutions   to the   problem, Six Sigma framework (DMAIC)  was used  which combined with the concept  of Lean Manufacturing to eliminate non-value added processes called ―Lean Six Sigma". Lean Six Sigma is a methodology for improvement which can be used for all processes with the aim to achieve better conditions, faster, cheaper, and safer.Three products selected as pilot project for improvement of products. As-is condition indicates the number of waste were identified that affect the efficiency of the line process. The target of this improvement is to eliminate waste and improve line efficiency. From the results of root caused analysis, can  implemented general and  specific  solutions  for  the  three  products.  In  this  case, implementing 5S, work standardization, escalation system, autonomous maintenance, and vision performance system become the solutions.All solutions are implemented aimed to improve line efficiency and reduce man hours that could affect the cost reduction.Saving from this project in a year is IDR 226 million. Keywords:  Unit Cost, Lean Six Sigma,Six Sigma,Lean Manufacturing, DMAIC]]>
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