<![CDATA[Background. The initial ECG at patients with Acute Coronary Syndrome, especially STEMI can predict size of infarction, response to reperfusion therapy and long term prognosis. A new classification, the QRS distortion have increased mortality rates and larger infarct size and less limitation of their infarct size by thrombolytic therapy. QRS distortion is the emergence of J point = 50% of R wave in leads with qR configuration (I, aVL, V4-V6), or disappearance of the S wave in leads with Rs configuration (V1-V3). Methods and results.This study is cohort-retrospective to patients with anterior IMA treated by thrombolytic at National Cardiovascular Centre – Harapan Kita, Jakarta, Indonesia, during January 2003 – September 2004, that fulfill inclusion and exclusion criterias. They were divided into two group, with QRS distortion (+) and without QRS distortion (-); each group consist of 30 patients. Correlation between the two groups were ana-lyzed by t test, chi-square test, Mann Whitney u test and logistic regres-sion. Patients age range is 40 – 69 years, and mostly man. There is no difference between baseline characteristic in the two groups, except cho-lesterol LDL which is higher in the group with QRS distortion. Patients with QRS distortion have a higher tendency of thrombolytic therapy fail-ure compare to patients without QRS distortion, (p=0,003). As the con-sequence they also have a higher rate of arrhythmia events, low ejection fraction and re-hospitalization due to congestive heart failure.Conclusions. The prognosis of patients with anterior IMA associated with QRS distortion is worse than without QRS distortion.]]>
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