Of All Antioxidants, Would One Finally Be Used Clinically For Atherosclerotic Disease?

Suko Adiarto (Departemen Kardiologi dan Kedokteran Vaskular FKUI, Pusat Jantung Nasional Harapan Kita, Jakarta.)

Indonesian Journal of Cardiology
Vol. 34, No. 1 Januari - Maret 2013

Oxidation of LDL by oxygen free radicals results in unregulated uptake of modified LDL by macrophages in arterial wall. This is considered a key initiating factor for development and progression of atherosclerotic process. It is then logical to hypothesize that anti-oxidants, which can directly scavenge free radicals, can be useful in preventing atherosclerotic process. Initial support for this hypothesis accumulated rapidly from numerous in-vitro studies.