Jurnal Health Sains
Vol. 3 No. 5 (2022): Jurnal Health Sains

Identifikasi Senyawa Mdma dan Paracetamol dalam Sampel Urine Menggunakan Metode Kromatografi Lapis Tipis dan Kromatografi Gas – Spektrofotometri Massa (Gc-Ms)

Adella Aisiyah (Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang)
Ajeng Nita Aryani (Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang)
Diva Rizqi Salsabilla (Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang)
Putri Mutiara Iskandar (Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang)
Silvana Lestari Irwansyah (Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang)



Article Info

Publish Date
24 May 2022

Abstract

MDMA (3,4-methylenedioximet amphetamine) is a semisynthetic compound derived from stimulant type amphetamine (ATS) which works by triggering the release of serotonin. Paracetamol (acetaminophen) is one type of drug that has an analgesic-antipyretic effect. MDMA analysis requires a relatively fast method, so the TLC method was chosen. The identification test was carried out using 3 chromatographic systems, namely methanol: ammonia TA (100:1.5 v/v), methanol: butanol TAF (60:40 v/v), and Toluene: acetone: ethanol: ammonia TAEA (45: 45: 7: 3v/v/v/v). The determination test was carried out using the TAEA system and MDMA was used as a standard. The results of the identification test showed that the sample contained MDMA through the Hrfc and spectrum approaches. Qualitative Analysis of Paracetamol Compounds (Acetaminophen) in Urine aims to analyze paracetamol compounds (acetaminophen) in urine qualitatively by using gas chromatography - mass spectrometry (GC-MS). Extraction of paracetamol in urine samples was carried out using ethyl acetate, which was then derivatized using BSTFA containing 1% TMCS and analyzed using gas chromatography – mass spectrometry (GC-MS). The results showed that urine samples at 1, 2, and 3 hours after consuming paracetamol gave positive results for acetaminophen-TMS while at 24, 168, and 720 hours after consumption they were negative.

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Journal Info

Abbrev

jhs

Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Description

Jurnal Health Sains adalah jurnal yang diterbitkan sebulan sekali oleh Ridwan Institute. Jurnal Health Sains akan menerbitkan artikel ilmiah dalam lingkup ilmu kesehatan. Artikel yang diterbitkan adalah artikel dari penelitian, studi atau studi ilmiah kritis dan komprehensif tentang isu-isu penting ...