The Difference in Serum Levels of IP-10 in Pulmonary Tuberculosis Patients with Positive AFB and AFB Conversion

Said Muchsin (Department Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah Kuala)
Herry Priyanto (Department Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah Kuala)
Teuku Zulfikar (Department Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah Kuala)
Novita Andayani (Department Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah Kuala)
Budi Yanti (Department Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah Kuala)
Ferry Dwi Kurniawan (Department Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Syiah Kuala)

Jurnal Respirologi Indonesia
Vol 42, No 3 (2022)

Background: Tuberculosis (TB) is caused by Mycobacterium tuberculosis, which most commonly infects the lungs. Diagnostic modalities are required in smear-negative TB. IP-10 is a potent chemokine for detecting the presence of TB infection. This study aimed to determine the difference in serum IP-10 levels in patients with smear-positive pulmonary TB and pulmonary TB patients with AFB conversion after two months of therapy.Methods: This was an analytic observational study with a cross-sectional approach. Sampling was carried out by consecutive sampling methods. AFB examination was performed using Ziehl-Neelsen staining, and serum IP-10 was measured using ELISA.Results: The study results obtained mean IP-10 levels in TB patients with smear positive and AFB conversion after two months of treatment of 459 pg/mL and 204.4 pg/mL, respectively. Statistical analysis using independent t-test received P<0.0001. The optimal cut-off value was 306,1 pg/ml (90% sensitivity; 95% specificity; area under the curve: 0.948, 95% CI=0.88-1; P=0.0001). Conclusion: There was a significant difference between IP-10 levels in TB patients with smear positive and AFB conversion