Acta Pharmaciae Indonesia : Acta Pharm Indo
Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo

Optimizing effervescent granules of blue pea (Clitoria ternatea L) flower ethanol extract as antioxidant

Tuti Sri Suhesti (Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia))
Warsinah Warsinah (Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia))
Pitra Wulandari (Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia))



Article Info

Publish Date
27 Jul 2022

Abstract

Background: Blue pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the blue pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Blue pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of blue pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected the effervescent granule preparation's flow rate, dissolution time, and pH.

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Journal Info

Abbrev

api

Publisher

Subject

Medicine & Pharmacology

Description

Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical ...