Makara Journal of Science
Vol. 23, No. 4

A Mathematical Model of Regulatory Mechanisms of Hepatocytes and Hepatitis B

Saidalieva, Mahruy (Unknown)
Hidirova, Mohiniso Baxromovna (Unknown)
Turgunov, Abrorjon Makhamatsolievich (Unknown)



Article Info

Publish Date
20 Dec 2019

Abstract

The study of the functioning of hepatitis B viruses in liver cells using methods of mathematical modeling is considered one of today’s pressing issues. In this article, the domains of functional- differential equations in a mathematical model of regulatory mechanisms of hepatocytes interacting with hepatitis B viruses (HBV) are presented. Characteristic molecular genetic systems regulatory mechanisms of the interrelated activities of liver cells and HBV are analyzed. A series of computational experiments show that the “chaos” and “black hole” theories describe two of the more dangerous regimes. As a result of the analysis of the “chaos” regime, small regions with normal behavior, “r-windows” were revealed. These regions allow the system to move from a “chaos” regime to a “regular” or normal regime. The features of the area of the regulatory activities of molecular genetic mechanisms of hepatocytes and HBV under a chaotic regime were characterized by analyzing the dynamics of the Lyapunov exponent. Small regions with regular behavior, “r-windows” in the field of dynamic chaos were defined. The regulatory nature of hepatocytes and HBV can be moved from the region of dynamic chaos to the normal region by using “r-windows”. The results of a computational experiment quantitatively analyzing the regulatory mechanisms of liver cells and HBV are presented.

Copyrights © 2019






Journal Info

Abbrev

publication:science

Publisher

Subject

Description

Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and ...