Jurnal Farmasi Sains dan Praktis
Vol 6 No 1 (2020)

CYTOTOXIC ACTIVITY OF COMBINED FIG EXTRACT AND OLIVE OIL AGAINST BREAST CANCER CELLS

Naniek Widyaningrum (Universitas Islam Sultan Agung)
Atina Hussana (Universitas Islam Sultan Agung)
Reza Saeful Adi (Universitas Islam Sultan Agung)
Memi Tiastuti (Universitas Islam Sultan Agung)
Karina Misti Utami (Universitas Islam Sultan Agung)



Article Info

Publish Date
26 Apr 2020

Abstract

Figs and olive oil are plants containing flavonoids compounds. Flavonoids have antioxidant and cytotoxic activities. This study aims to find out the antioxidant and cytotoxic activities of fig extract, olive oil and combination of fig and olive oil as well. Study using a combination of tin and olive oil with a combination of extracts of 1: 0.1: 3, 1: 1, 3: 1, 0: 1. Cytotoxic and antioxidant activities were tested using MTT assay and DPPH method. Cytotoxic test results were analyzed using probit and antioxidant tests using linear regression. Test results from a single olive on T-47D cells have very strong cytotoxic and antioxidant activities (560,769 and 33.27 µg / ml). In MCF-7 cells the ratio of figs and olives 1: 1 has very strong antioxidant and cytotoxic activity (576,459 and 76.79 µg / ml), in 4T1 cells the ratio of fruitbtin and olive combination of 3: 1 has no cytotoxic activity but has antioxidant activity very strong (1733,517 and 21.81 µg / ml). The combination of fig extract and olive oil had cytotoxic activity on T-47D and MCF-7 cells, but did not have cytotoxic activity on 4T1 cells. This combination had very strong antioxidant activity in T-47D and 4T1 cells, strong in MCF-7 cells.

Copyrights © 2020






Journal Info

Abbrev

pharmacy

Publisher

Subject

Immunology & microbiology Medicine & Pharmacology Public Health

Description

Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science ...