Effect of formaldehyde-based additive against African swine fever virus in complete swine feed

V. D. Ly (Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR))
T. V. Hoang (Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR))
A. K. Dang (Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR))
S. Aupanun (Department of Research and Development, LINQ Technology Corporation)
C. Wongpukdee (Department of Research and Development, LINQ Technology Corporation)

Journal of the Indonesian Tropical Animal Agriculture
Vol 47, No 3 (2022): September

African swine fever (ASF) is currently considered the serious contagious disease of the swine in-dustry worldwide. The feed and feed ingredients have been recognized as a potential risk factor for Af-rican swine fever virus (ASFV) transmission. No commercial vaccines and effective drugs against ASFV are available to date. This study aimed to examine the antimicrobial SALTEC™ 512, a formal-dehyde-based additive, at an application rate of 1.0; 2.0; and 3.0 kg/t feed against ASFV in complete swine feed. The effect of SALTEC™ 512 was evaluated by a contaminated ASFV feed assay. Our study reveals that SALTEC™ 512 inactivated ASF/VN/Pig/Hue/1270 strain in complete swine feed at an inclusion rate of 1.0 kg/t feed on Day 1 post inoculation. The most effective action was noticed at an inclusion level of 3.0 kg/t feed on Day 7 post inoculation. The antiviral activity of SALTEC™ 512 against ASF/VN/Pig/Hue/1270 was dose and time-dependent. Overall, SALTEC™ 512 may be a po-tential additive to reduce the risk of ASFV transmission via feed contamination.