SAAT PARASIT MEMBASMI PARASIT: UJI EFEKTIVITAS EKSTRAK BENALU SEBAGAI TERAPI MALARIA BARU

Budi, Danang Setia ( Pendidikan Dokter, Fakultas Kedokteran, Universitas Gadjah Mada)
Baskara, Anak Agung Ngurah Nata ( Pendidikan Dokter, Fakultas Kedokteran, Universitas Gadjah Mada)
Putra, Pramana Pananja ( Pendidikan Dokter, Fakultas Kedokteran, Universitas Gadjah Mada)
Faiqoh, Zulfa ( Pendidikan Dokter, Fakultas Kedokteran, Universitas Gadjah Mada)
Solikhah, Eti Nurwening ( Bagian Farmakologi dan Terapi, Fakultas Kedokteran, Universitas Gadjah Mada)

Program Kreativitas Mahasiswa - Penelitian
PKM-P 2013

Nowadays, the antimalarial drug used showed resistances. Scientists look for new drugs by research especially using herbal plans. The mistletoe(Dendrophthoe pentandra) is previously known having antimalarial activity. This study was conducted to determine in vitro antiplasmodial activity, mechanism of heme polymerase inhibition, and cytotoxicity of water and ethanol extracts of Dendrophthoe pentandra against Vero cells.The results showed that water and ethanol extract of Dendrophthoe pentandra has in vitro antiplasmodial activity, inhibition of polymerase heme, and cytotoxic effect on Vero cells with IC50 values.It can be concluded that Dendrophthoe pentandra has potency as an antiplasmodial.Keywords          :Dendrophthoe pentandra, antiplasmodium, heme polymerase, cytotoxic, Vero cell