Indonesian Journal of Rheumatology
Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology

Quantitative Evaluation of Proteinuria with Urinalysis Test and Comparing Its Correlation with Random Spot Urine PCR and 24-Hour Urine Protein in SLE Patients: Analysis of proteinuria

Chun Ruh Ng (Unit Rheumatology, Department of Medicine, Hospital Sultan Ismail, Johor Bahru, Johor, Malaysia)
Yet Lin Loh (Unit Rheumatology, Department of Medicine, Hospital Sultan Ismail, Johor Bahru, Johor, Malaysia)
Dawan Khadijah (Department of Pathology, Hospital Sultan Ismail, Johor Bahru, Johor, Malaysia)



Article Info

Publish Date
14 Dec 2022

Abstract

Introduction: Lupus nephritis is an important concern among systemic lupus erythematosus (SLE) patients in Asia, and its mortality rate was reported to be 6 times higher compared to the general population. 24-hour urine protein collection has long been used as the gold standard test to assess proteinuria. This study aimed to assess the correlation of urinalysis test with random spot urine protein-creatinine ratio (PCR) compared with 24- hour urine protein. Methods: This was a retrospective study. The electronic medical records of all SLE patients seen in the rheumatology clinic of Hospital Sultan Ismail from 1st January 2017 to 1st January 2021 were reviewed. Patients who had urinalysis, urine protein-creatinine ratio, and 24-hour urine protein tests were identified. Data on demography, urinalysis, random spot urine protein-creatinine ratio, and 24-hour urine protein were obtained and analysed. Results: The correlation between urinalysis and 24-hour urine protein was strong (r=0.702), whereas the correlation between urinalysis and urine PCR was stronger (r=0.797). Our study also showed the correlation between random urine protein-creatinine ratio and 24-hour urine protein is strong (r=0.782). Conclusion: Urinalysis correlates well with both random spot urine protein-creatinine ratio and 24-hour urine protein, and the correlation is stronger with urine protein-creatinine ratio.

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Journal Info

Abbrev

ijr

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Rheumatology is a peer-reviewed open access journal on rheumatic diseases and connective tissue disorders. This is an official journal of Indonesian Rheumatology Associantion (IRA) and published twice a year since 2009. Our mission is to encourage the development of scientific ...