Objective : The objective of this case report is to describe the effectiveness of systemic fluconazole against oropharyngeal candidiasis in HIV / AIDS patients. Case Report : A woman 36 years-old, came with chief complaint of white plaques on entire oral mucosa since one month ago followed by pain when swallowing. The patient has been suffered from pulmonary tuberculosis since 2 years ago and diagnosed with HIV while undergoing antituberculosis drug therapy. Intra oral examination, white plaques were found on the dorsum of the tongue, soft palate and especialiced on oropharynx. Results: Therapy was given by fluconazole, vitamin B12, folic acid and chlorhexidine gluconate 0.2% mouthwash. The oral lesions was improved within 3 days of therapy. She decided to avoid the stigma of the community in her environment about HIV / AIDS sufferer, patient choose to seek treatment at other health services that are located far from where she lives. Conclusion: Systemic fluconazole is the drug of choice for oropharyngeal candidiasis in HIV patients.
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