Introduction: Low self-efficacy that occurs in chronic renal failure patients undergoing hemodialysis therapy not only has an effect on physical disorders but also has an effect on the occurrence of patient psychiatric disorders. There needs to be a scientific study on improving self-efficacy, one of which is guided by the health promotion model theory. Method: The design of this study is cross-sectional. The study sample totaled 139 respondents. The sampling technique uses executive sampling. Respondents were selected based on inclusion and exclusion criteria. The research instrument uses a questionnaire of self-efficacy, biological, psychological and sociocultural factors. The data obtained were processed using spearman rank and logistic regression. Results: This study found that biological, psychological, and sociocultural factors are associated with the self-efficacy of hemodialysis patients with a p-value = 0.000 less than 0.05. Psychological factors most influence self-efficacy with p-value = 0.000 less than 0.05, and biological and social factors affect self-efficacy with p-value = 0.004 less than 0.005. Conclusion: Biological, Psychological and Socialcultural Factors based on the theory of health promotion model are related to self-efficacy and can affect self-efficacy in chronic renal failure patients undergoing hemodialysis therapy. Abstrak: Pendahuluan: Rendahnya self-efficacy yang terjadi pada pasien gagal ginjal kronik yang menjalani terapi hemodialisa tidak hanya berefek pada gangguan fisik, namun juga berefek pada terjadinya gangguan psilkologis pasien. Perlu adanya kajian ilmu dalam meningkatkan self-efficacy tersebut salah satunya berpedoman kepada teori health promotion model. Metode: Desain penelitian ini adalah cross sectional. Sampel penelitian berjumlah 139 responden. Teknik pengambilan sampel menggunakan excecutive sampling. Responden dipilih berdasarkan kriteria inklusi dan eklusi. Instrumen penelitian menggunakan kuesioner self-efficacy, faktor biologis, psikologis dan sosialkultural. Data yang diperoleh diolah menggunakan spearman rank dan regresi binary logistik. Hasil: Penelitian ini memperoleh hasil bahwa faktor biologis, psikologis dan sosialkultural berhubungan dengan self-efficacy pasien hemodialisa dengan nilai p value = 0,000 kurang dari 0,05. Faktor psikologis paling mempengaruhi self-efficacy dengan p value = 0,000 kurang dari 0.05, dan faktor biologis serta sosialkulutural mempengaruhi self-efficacy dengan p value = 0,004 kurang dari 0,005. Kesimpulan: Faktor Biologis, Psikologis dan Sosialkultural berdasarkan theory health promotion model berhubungan dengan self-efficacy dan dapat mempengaruhi self-efficacy pada pasien gagal ginjal kronik yang menjalani terapi hemodialisa.
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