<![CDATA[Currently, many studies have proven that excessive fat consumption can trigger various disorders, such as obesity, dyslipidemia, hypertension, impaired glucose tolerance. This study aimed to examine the effect of a high-fat diet on lipid profiles and fasting blood sugar in the serum of white rats (Rattus norvegicus) Wistar strain. This study is a true experimental study with a randomized posttest-only control group design using 31 male Wistar rats weighing 150-250 grams, aged 4-5 months. Rats were divided into two groups, namely group K1 (negative control, normal diet) amounted to 7 and K2 (high-fat diet, with daily fat content of 66.28%) amounted to 24 mice. A high-fat diet was given for 50 days. The parameters examined were triglyceride levels, HDL cholesterol, and fasting blood sugar. The K1 group had an average triglyceride level of 52.16 mg/dL, HDL cholesterol 51.80 mg/dL, and fasting blood sugar 157.20 mg/dL; while the K2 group had an average triglyceride level of 101.00 mg/dL, HDL cholesterol 42.93 mg/dL, and fasting blood sugar 208.00 mg/dL. Based on the results of independent T-test analysis, the levels of triglycerides, HDL cholesterol, and fasting blood sugar in groups K1 and K2 were significantly different, namely 0.030, 0.011 and 0.009, respectively (P < 0.05). It can be concluded that a high-fat diet affects the lipid profile and fasting blood sugar. Keywords: high-fat diet, lipid profile, triglyceride, HDL cholesterol, fasting blood sugar, Rattus norvegicus]]>
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