<![CDATA[In general, negative binomial regression is used for univariate discrete data that is overdispersive and follows the Poisson distribution. In the real world, a case is often influenced by two discrete variables that are correlated with each other. Therefore, in this paper we will examine the regression that is influenced by two independent variables, has overdispersion properties and follows a bivariate Poisson distribution. This regression is called bivariate negative binomial regression with model parameters estimated using the Maximum Likelihood Estimation (MLE) method and Newton Raphson iterations. The formation of this model is based on the Famoye method, while in general it uses the Cheon method. Furthermore, the results of this study were applied to data on the number of maternal and infant deaths in South Sulawesi Province in 2020. The results obtained were the number of puskesmas that had a significant effect on the number of maternal deaths and the proportion of handling obstetric complications, the proportion of pregnant women implementing the K4 program, the proportion of deliveries in facilities health services, the proportion of postpartum mothers implementing the KF2 program and the number of puskesmas have a significant effect on the number of infant deaths.]]>
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