Journal of Global Pharma Technology
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Synthesis and Characterization of Mixed Ligand Complexes Contain Curcumin, Schiff Base and Azide (N3‾) with Some Metal ions and Evaluation their Antibacterial Activity

Sagid M. Lateef (Unknown)



Article Info

Publish Date
05 Apr 2018

Abstract

The research included the synthesis and characterization of new Schiff Base (L3) by reaction 2-aminopyridine and isatin , also included synthesis and characterization of mixed Ligand  complexes using curcumin (essential "HL1", Schiff base (secondary Ligand "L3"), and Azide ion (N3‾) ( secondary Ligand)  with some metal ions and evaluation of antibacterial activity in general formula:  [M(L1)(L3)(N3)H2O]  where : M = [Co(II) , Ni(II) , Cu(II)]  M (L1) (L3) (N3)]       where:  M= [Mn (II), Zn (II), Cd (II), Hg (II)]  With M: L1: L3, 1:1:1 Mole ratio using ethanol as a solvent. The complexes were characterized by using physical methods and spectroscopic (FT -IR, UV-Vis, mass)  along with C.H.N. ,the chloride content and designate the percentage of the metal in addition to measurements of  molar conductivity From the above data we suggested an octahedral geometry for all complexes. Antibacterial activity of ligands and  their complexes was estimated for four types of   bacterial Staphylococcus aureu, Bacillus subtilis, Eterobactern, Escherichia Coli, the results of antibacterial activity showed that their compounds prepared effective against bacteria.Keywords: Curcumin, Schiff base, Mixed ligands complexes.

Copyrights © 2018






Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...