Journal of Global Pharma Technology
Volume 11 Issue 03

Synthesis, Characterization and Evaluation the Biological activity for New Mesogenic 1, 3-oxazepine-4, 7-dione Derived from Trimesic Acid

Nasreen R. Jber (Unknown)



Article Info

Publish Date
16 Nov 2016

Abstract

In this work new liquid crystalline oxazepine compounds derived from trimestic acid were prepared. In the first step, 1, 3, 5-tris-[3-thiol-4-amino-1, 2, 4 triazole-5-yl] benzene [E] was synthesized through the preparation of 1, 3, 5-benzenetricarboxylic acid hydrazide [C]. The second step was the condensation reaction between different aldehydes: 4-hexyloxybenzaldehyde, 4-heptyloxybenzaldehyde and 4-octyloxybenzldehyde to yield new Schiff bases compounds [F1-F3] respectively. In the final step, oxazepine compounds [G1-G3] were prepared from reaction imines compounds [F1-F3] with succinic anhydride in dry benzene. All these derivatives were characterized via FTIR spectroscopy, elemental analysis and 1H-NMR spectroscopy. Polarizing optical microscope and DSC were used to assessment the mesomorphic properties of the synthesized compounds. The synthesized compounds [G1-G3] were examined for antibacterial activity against Staphylococcus aureous, Staphylococcus saprophyticus (Gram-positive) and Kelebsiella pneumonia, Escherichia Coli (Gram-negative).Keywords: 1, 3-oxazepine-4, 7-dione, 3-mercapto-4-amino- 1, 2, 4- triazole, Liquid cystal, Antibacterial activity.

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Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...