Journal of Global Pharma Technology
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Synthesis , Characterization , Antimicrobial of Studies New 2,2'-[(1Z,2Z)-ethane-1,2 diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and their transition metal complexes

Ibrahim . A Flifel (Unknown)



Article Info

Publish Date
09 Apr 2018

Abstract

A new ligand 2,2'-[(1Z,2Z)-ethane-1,2-diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and its Cr(III) , Co(lll) and Ni(ll) complexes were synthesized . The new ligand and its complexes have been characterization on the basis their spectra of 1HNMR, mass, Fourier transform infrared (FTIR) , as well as magnetic susceptibility, elemental analysis[C,H,N] and conductance measurements  . The program of Hyperchem 7.51 has been used up for theoretical accounts using PM3 method [1] to study the electrostatic potential that provided good information about the complexity site. Of the results obtained we can suggested octahedral geometrics for Cr (III) and Co (III) complexes, while tetrahedral geometry for Ni (II) complex .A ligand and its complexes were screened for their antibacterial activity against two kinds of strains Escherichia coli (gram negative bacterial strains) and staphylococcus aureus (gram positive bacteria strains), This research showed excellent results in comparison with Ciprofloxacin as standard drug. Keywords: ligand, complexes, Characterization, Hyperchem, electrostatic potential, antibacterial.     

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Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...