Journal of Global Pharma Technology
Volume 11 Issue 2: 2019

Synthesis, Characterization & Evaluation of Biological Efficiency of Some Transition Metal Complexes with Schiff Base E-3-(Phenylhydrazono) indolen-2-one

Israa A. Al-H. Hamdan (Unknown)



Article Info

Publish Date
16 Nov 2016

Abstract

This work involved synthesis of Schiff base derivative from the condensation reaction of the phenylhydrazine with 1H-Indole-2, 3-dione (isatin). Metal complexes of the Schiff base ligand with Cu (II), Zn (II), Fe (III), Ni (II), and Mn (II) ions were prepared by reacting ligand with the metal salts in ethanol. The chemical structures of the ligand as well as the stereo-chemical structures and geometries of the studied metal complexes were suggested depending on the results obtained from CHN analysis, H-NMR, FT-IR spectrophotometer, Uv-vis electronic spectra, conductivity measurements, and magnetic measurements. The mole ratio of the ligand to the metal ion was 1:2 with bi-dentate bonding behaviors of the coordinating ligand with the metal ions. The Metal complexes of the Schiff base ligand that prepared show variety of bioactivity against three types of bacteria. Keywords: Isatin, Schiff Bases, Metal Complexes, Antibacterial activity, Data spectra.

Copyrights © 2019






Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...