<![CDATA[Introduction previous studies have referred to the moderating effect of devil's claw on appetite process. Obestatin is a peptide with 23 amino acids secreted from parietal cells of gastric mucosa. This hormone inhibits food intake and body weight reduces. This study was conducted to study the effects of hydroalcoholic extract of devil's claw on serum levels of obestatin and body weight in male ratsMethod In this experimental study, 40 male Wistar rats with an average weight of 180-200 g were randomly divided into 5 groups of 8 animals (control, testator, and the experimental groups receiving the hydroalcoholic extract of devil's claw in concentrations of 150, 300 and 600 mm g per kg of body weight). Hydroalcoholic extract of devil's claw (HAEDC) was administered to animals in gavage for 28 consecutive days. One day after the last injection, the rats were weighed, and after getting blood samples and separation of serum, obestatin concentration was measured using ELISA kits for rats. Data analysis was performed using ANOVA with SPSS 21 and Duncan's test.Results 300 and 600 mg/kg of HAEDC significantly increase serum levels of obestatin and reduce body weight compared to the control group (p<0.05).Conclusion HAEDC reduces body weight by increasing secretion of obestatin that restrains the appetite.Keywords: devil's claw, Obestatin, Body weight, Rat.]]>
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