Journal of Global Pharma Technology
Volume 10 Issue 09: (2018) September 2018

In Vitro Antioxidant Anti-inflammatory and Acute Toxicity Study of Root Extract of Asparagus Racemosus

Ramesh L. Londonkar (Unknown)



Article Info

Publish Date
03 Sep 2018

Abstract

The purpose of the study is to investigate potential of antioxidant, Anti-inflammatory and acute toxicity study of ethanol root extract of Asparagus racemosus Linn (ASR). The antioxidant activities were evaluated using in vitro Ferric reducing power, Free radical scavenging activity by DPPH method, hydroxyl radical scavenging activity, Nitric oxide radical scavenging activity, Super oxide Anion Radical Scavenging Activity and total antioxidant capacity. The anti-inflammatory potential was also evaluated using Hyaluronidase inhibition assay. The effect was compared with a known antioxidant agent (BHA/Ascorbic acid). It was found that the extract at different concentration exhibited a significant dose dependent antioxidant and anti-inflammatory effect. Acute toxicity study was performed in Wistar rat and an OECD guideline 423 was followed, No sign of toxicity was observed after treating with 2000 mg/kg of ASR.Keywords: Asparagus racemosus, Free radical, acute toxicity, Hyaluronidase inhibition. 

Copyrights © 2018






Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...