Journal of Global Pharma Technology
Volume 11 Issue 2: 2019

Synthesis and Characterization of Some New Pyrazole Derivatives

Nisreen H. Kar (Unknown)



Article Info

Publish Date
16 Nov 2016

Abstract

This work contain many steps starting from esterification of  isophthalic acid to yield diester compound [I] which was converted to their acid hydrazide [II], then the later compound reacted with ethylacetoacetate  to  yield pyrazol-5-one compound [III]. Afterword added acetyl chloride to give the compound [IV], the reaction of this compound with theiosemicarbazide led to produce a new carbothioamide compound [V], which was reacted with ethyl chloro acetate to yield the thioxoimidazolidin compound [VI]. The condensation reactions of this compound with different substituted aldehyde give new alkene derivatives [VII] a-d. The synthesized compounds were characterized by melting points, FT-IR, 1H-NMR and Mass spectroscopy.Keywords: Pyrazole, Heterocyclic, Isophthalic acid, Acid hydrazide, Alkene derivatives.

Copyrights © 2019






Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...