Journal of Global Pharma Technology
Volume 10 Issue 06: (2018) June 2018

Synthesis, Characterization and Biological Activities of New Azo Dyes -Azomethine Compound and Their Metal Complexes

Rehab Al-Hassani (Unknown)



Article Info

Publish Date
11 Jun 2018

Abstract

The new ligand (2-thioxo-5-((4-(1-(p-tolylimino) ethyl) phenyl) diazenyl) dihydropyrimidine-4, 6(1H, 5H)-Dione (R1) have been synthesized and characterized by micro elemental analysis, Mass, (1H-13C) NMR, FT-IR, and UV-Vis spectroscopic techniques. (R1) acts as a ligand coordinating with some metal ions Co(II), Ni(II), Cu(II), Au(III) and Pt(IV) generated fife mononuclear metal complexes, represented as [CoR1Cl2(H2O)2] (a) , [NiR1Cl2] (b) , [CuR1Cl2] (c), [Pt(R1)2Cl2]Cl2(d) , [Au(R1)2]Cl3(e) .The Structures of the new compounds were characterized by elemental , FT-IRĀ  and UV-Vis Spectra. The magnetic properties and electrical conductivities of metal complexes were also determined. The antibacterial activity for the (R1) and its metal complexes were studied against two types of pathogenic bacteria (Escherichia coli, and Staphylococcus aureus) Furthermore, the antifungal activity against two fungi) Candida albicans, and Aspergillusflavus (was studied for (R1) and its metal complexes. The anticancer activities of the ligand and their metal complexes have been extensively studied on The La cancer cell line.

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Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...