Journal of Global Pharma Technology
Volume 11 Issue 05.

Identification of Some New Tetrazole and Thiazolidine Derivatives Synthesized From 4-Chlorobenzoic Acid and Evaluation Their Antibacterial Effect

Maysoon Tariq Tawfiq (Unknown)



Article Info

Publish Date
16 Nov 2016

Abstract

The research  includes  the synthesis of some new derivatives of  tetrazole and thiazolidine  rings from the reactions of  2- (4-chlorophenyl)-5-hydrazinyl- 1,3,4-oxadiazole [4] with various substituted aromatic aldehydes  in absolute ethyl alcohol as  a  solvent and presence of glacial acetic acid as a catalyst to form Schiff's  bases [5-10]. The prepared new Schiff's bases [5 -10] reacted with sodium azide , and mercaptoacetic acid in THF to yield five membered rings  (tetrazole ring) [11-15], and (thiazolidine ring) [16-20]  in good products. The  spectral  methods  of  the   prepared  compounds  were  characterized  by FT.IR, and 1HNMR for compounds [9,13,14,and 19] , besides melting points were recorded , and the purity was checked through T.L.C. technique. Antibacterial activities for some of the synthesized compounds were examined.Keywords: Heterocyclic compounds, 4-Chlorobenzoic acid, Acid hydrazide, Oxadiazole, Schiff’s bases, Tetrazole, Thiazolidine, Biological activity.

Copyrights © 2016






Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...