Journal of Global Pharma Technology
Volume 11 Issue 07

Indirect Method for Determination Desferal in Pure and Pharma-ceutical Formulations Using Cerium (IV) As a Chelating Element

Ashraf Saad Rasheed (Unknown)



Article Info

Publish Date
16 Nov 2016

Abstract

Objective: The present study includes indirect analytical method for the determination of the drug desferal (DSFM) in some pharmaceutical dosages using molecular absorption. DSFM was usually used for treating such diseases like Thalasemia and Alzheimer. Methods: The proposed method is built on reaction between DSFM and cerium (IV) ion to forms an orange chelate complex (λ max = 443 nm) at pH 6. Results: The optimal experimental condition for the chelate formation: pH=6; concentration of Ce(IV) (30 mg L-1); maximum reaction time (10 min.); lmax=443 nm; metal -to- ligand (1:1) ratio.  Analytical figures of merits: linear dynamic range (1-110) mg L-1; r = 0.9996, S = 0.9996 mg.cm-2), D.L (0.167) mg L-1; Erel. % 1.26; recovery% 100.2; RSD% 1.460.Conclusion: The developed method was successfully applied to the estimate of DSFM in pharmaceutical samples.Keywords: Desferal, Spectrophotometric, Cerium sulfate tetrahydrate, Pharmaceutical dosages.

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Journal Info

Abbrev

jgpt

Publisher

Subject

Medicine & Pharmacology

Description

ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and ...