Study the Pharmacological Effect of Letrozole and Gonadotropine on the Level of Serum Glycoprotein’s (HRG, Inhibin B, and AMH) in Infertile Women and their Effect on Stimulating Ovulation

Narjis Hadi Al-Saadi

Journal of Global Pharma Technology
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Objective: To study the effect of medication (letrozole, and gonadotropine) on ovulation induction and its relation with glycoproteins. Methods: Thirty-three infertile women were enrolled from outpatient women’s clinic and twenty-two healthy fertile women were enrolled as a control group. Their ages ranges from (15 to 44) years old. Histidine Rich Glycoprotein (HRG), Inhibin B and Anti Müllerian hormone (AMH) concentrations were measured in sera using (ELISA) technique. Results: Follow-up examinations four months after receiving treatments revealed a significant raise in serum HRG concentration (p=0.01) and a considerable decrease in serum AMH concentration (p=0.04) among infertile women. Pelvic ultrasonography, showed a significant (p = 0.000) increase in the size and the number of oocytes in both left and right ovaries infertile women.  Conclusion: Letrozole and gonadotropin treatments are effective in changing the levels of HRG and AMH in infertile women. Keywords: Women infertility, HRG, Inhibin B, AMH, letrozole, gonadotropin.