Neonatal mortality in Rembang regency, Central Java province, has raised concerns to solve comprehensively. This study aimed to observe distributions and examine determinants of neonatal mortality in the Rembang regency. A case-control study was conducted to examine 50 cases and 50 control by the medical records in the Department of Health. There were 11 variables: parity, mother's age, gestational age, a congenital defect, neonatal sepsis, neonatal asphyxia, pregnancy complication, birth weight, labour locations, childbirth helper, and type of labour. The analysis consists of bivariate with chi-square and multivariate by logistic regression. The most frequent risk factors are gestational age (P=0.00; OR=18.4; and CI=5.04-67.00) and birth weight (P=0.00; OR=14.7 and CI=4.96-43.51), yet logistic regression found high-risk birth weight (P=0.01; aOR=5.4 and CI=1.43 – 20.34) and high-risk gestational age (P=0.03; aOR=5.8 and CI=1.22-27.59) are significant on neonatal mortality in Rembang regency, Central Java Indonesia. This finding is essential in taking policy action on safe pregnancy among high-risk women in the Rembang regency.
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