<![CDATA[Case-based reasoning is a methodology for solving problems by utilizing previous experience. In this study the authors apply case-based reasoning to diagnose sexually transmitted infection using the weighted Euclidean distance method. Source of the knowledge base was obtained by collecting medical record of patients with sexually transmitted infections in 2016-2017. The process of finding a solution starts with eliminating irrelevant data using the C4.5 method and continues with the calculation of the similarity value using the Weighted Euclidean Distance algorithm. This system can diagnose 5 types of sexually transmitted infections based on 123 existing symptoms. System result in the form of sexually transmitted infections based on symptoms experienced by the patient, treatment solution and presentation of similarities between new cases and old cases. Based on the result of testing with 127 cases of sexually transmitted infections obtained result: testing uses the K-Fold Cross Validation scenario, the total data is divided into 10fold and the testing process is divided into 2 parts, namely testing using indexing and testing without using indexing. For testing using the highest accuracy indexing obtained at 90.84% in the second fold, and the average accuracy of the entire fold is 88.55% with the average time generated 9498 ms (millisecond), while testing without using the highest accuracy indexing obtained by 63.03% in the second fold, and the average accuracy of the entire fold is 53.48% with the average time generated 9975 ms (millisecond).]]>
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