JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
JKKI, Vol 14, No 1, (2023)

Successful combination therapy of low-dose aspirin and unfractionated heparin in recurrent pregnancy loss: A case report

Adhi Pribadi (Division of Maternalfetal, Department of Obstetrics and Gynecology, Universitas Padjadjaran, Bandung, Indonesia)



Article Info

Publish Date
05 Apr 2023

Abstract

Habitual abortion, defined as more than two consecutive pregnancy losses, affects approximately 1% to 2% of women. This pathological condition undoubtfully frustrates a woman, yet this condition still has a chance to be treated and achieve a favorable pregnancy outcome. This case report aims to describe the success of a pregnancy with a history of recurrent miscarriages (five times of baby loss). The administration of a combination of low-dose aspirin and unfractionated heparin offers a 72-80% chance of having a good pregnancy outcome. We present a P2A5 woman with Thalassemia Minor and thrombocytosis. Preventive treatment, prenatal diagnosis, pregnancy outcomes, and complications were reviewed. Combination therapy of 80 mg aspirin and 2 x 5000 U unfractionated heparin subcutaneously during the last two pregnancies were able to maintain the pregnancy and prevent early pre-eclampsia or Fetal Growth Restriction (FGR) but not late-onset one. In the 6th pregnancy, the patient experienced late-onset FGR with a minor congenital anomaly. In the 7th pregnancy, severe pre-eclampsia appeared. However, administration of combination of heparin and aspirin could maintain pregnancy and fetal viability in Thalassemia Minor patients with recurrent abortus and thrombocytosis.

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Journal Info

Abbrev

JKKI

Publisher

Subject

Medicine & Pharmacology Public Health

Description

JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and ...