Jurnal Kedokteran Hewan
Vol 14, No 1 (2020): March

SINGLE BULB GARLIC (Allium sativum) EXTRACT IMPROVE SPERM QUALITY IN HYPERLIPIDEMIA MALE MICE MODEL

Nosi Qadariah (Biology Education Program Study, Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia)
Sri Rahayu Lestari (Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia)
Fatchur Rohman (Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia)



Article Info

Publish Date
25 Apr 2020

Abstract

The aim of this research was to find out the influence of single bulb garlic on sperm quality improvement in hyperlipidemia model of male mice. Male mice (Balb-C, 12 weeks, bw 21±5 g) were given high fat diet for 45 days until their body weight achieved 45±5 g. The mice were then divided into six groups. The mice in the first group (control group (N)) was fed with 7 g higrow pokphan 551 per day. The mice in the second group (control negative group) was fed with 7 g high fat diet (HFD), while the mice in the third group (control positive group) were treated with statin at  dose of 0.91 mg. The mice in groups 4, 5, and 6 were treated with single bulb garlic extract at dose of 125 mg/kg bw, 250 mg/kg bw, and 500 mg/kg bw, respectively. On the 31st day, the male were dissected and cauda epididymis was taken and chopped in a sterile phosphat buffer saline (PBS) and observation conducted on sperm quality consisted of sperm count, sperm motility and sperm normality. The results indicated a significant increase in sperm count, motility and normality in mice treated with single bulb garlic extract at dose of 250 mg/kg bw.

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Journal Info

Abbrev

JKH

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

Description

Jurnal Kedokteran Hewan (J. Kedokt. Hewan), or Indonesian Journal of Veterinary Sciences is a scientific journal field of veterinary sciences published since 2007, published FOUR times a year in March, June, September, and December by Universitas Syiah Kuala (Syiah Kuala University) and Indonesian ...