Objective: This case report aims to describe effectiveness of single visit endodontic in pulpitis irreversible.Methode: A 30 year-old female was referred to Dental Hospital of Hasanuddin University with chief complaint tooth cavities of mandibular molar and pain ± 2 years ago, with the history of sudden pain and took paracetamol to relieve the pain. Patient did not go to dentist. Intraoral examination showed caries in  36, positive vitality, negative percussion and palpation. Radiograph showed normal periapical tissue. Endodontic treatment was performed in single visit endodontic with a single length preparation technique. Sequential irrigation was carried out using 5.25% NaOCl, 17% EDTA, and distilled water, and activated. Obturation performed with the single cone gutta percha technique with resin based sealer cement followed by direct composite restorationResult: Patient showed no complaints of pain and restoration was in good conditionConclusion: Single visit endodontic is an effective treatment for pulpitis irrversible
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