Journal Borneo
Vol. 3 No. 2 (2023): Volume 3 Issue 2 tahun 2023

Identifikasi Senyawa Alkaloid dari Ekstrak Etanol Kulit Batang Strychnos ligustrina Menggunakan Liquid Chromatography-Mass Spectrometry (LC-MS)

Siti Wanda Nurwanti (Prodi Farmasi, Politeknik Hang Tuah Jakarta)
Andriningrum Sarnoko (Prodi Farmasi, Politeknik Hang Tuah Jakarta)
Atika Wulandari (Prodi Farmasi, Politeknik Hang Tuah Jakarta)



Article Info

Publish Date
31 Jul 2023

Abstract

Bidara Laut (S. ligustrina) stem bark is commonly used by the society of West Nusa Tenggara and Bali as an antimalaria treatment. The study aims to quantify the number of chemical components from the alkaloid family present in the ethanolic extract of S. ligustrina bark. With a 70% ethanol-based solvent, the bark of S. ligustrina was extracted using the maceration process. LC-MS was used to assess the number of alkaloids present in the bark of S. ligustrina. In a reverse phase column using acetonitrile and formic acid as the mobile phases, gradient elution was carried out for 16 minutes. Five alkaloid compounds were discovered as a consequence of the investigation, including the 3-iso-ajmalicine molecule, which had an m/z of 353.1847 and a retention time of 4.26 minutes, and the brucine compound, which had an m/z of 395.1953 and a retention time of 5.06 minutes. The other 3 molecules are confirmed with m/z of that molecules C24H28N2O4, C22H24N2O3, and C11H17NO6 are 409.2107, 365.1848, and 260.1116, respectively, and their retention times are 4,90 minutes, 5,35 minutes, and 1,32 minutes. 3-iso-ajmalicine has just been confirmed to be present in S. ligustrina stem bark.

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Journal Info

Abbrev

jb

Publisher

Subject

Health Professions Medicine & Pharmacology Nursing Public Health

Description

Journal Borneo (J. Born.) publishes original, previously unpublished research articles, review articles, as well as short communication in various science technology, and health fields. Paper topics include the following: Pharmacy; Nursing; Midwifery; Public health; Health information technology; ...