EFEK PAPARAN ASAP BIOMASSA GAMBUT TERHADAP STRESS OKSIDATIF PADA TIKUS WISTAR

Uly Astuti Siregar Uly Astuti Siregar (Departement of Histology, Faculty of Medicine, Abdurrab University, Pekanbaru, Indonesia)
May Valzon (Departement of Anatomy, Faculty of Medicine, Abdurrab University, Pekanbaru, Indonesia)
Fitrianti (Departement of Pathology Anatomic, Faculty of Medicine, Abdurrab University, Pekanbaru, Indonesia)
Arif Budianto (Physics Study Program, University of Mataram, Mataram, Indonesia)

JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
JKKI, Vol 14, No 2, (2023)

Background: Indonesia ranks third in the world regarding air pollution due to forest and land fires; most of the land burned is a peatland. Particulate matter (PM) 2.5 is the largest component of the total smoke particles. Short-term and long-term exposure to PM2.5 remains a hazard to human health.Objective: This study aims to examine the effect of exposure to peat biomass smoke on serum malondialdehyde (MDA) levels and body weight of Wistar rats.Methods: Experimental animals were randomly divided into three groups: Control group (C) is not given treatment, and treatment groups (X1 and X2) are exposed to smoke from peat biomass of 100 g and 150 g of biomass for 60 seconds per day for 14 days. The body weight was examined before and after treatment, while Serum MDA levels were examined after treatment.Results: The results showed significant differences (p < 0.05) in serum MDA levels between groups. The highest serum MDA levels were found in group X2 (3.03 ± 0.185 nmol/ml), followed by group X1 (2.67 ± 0.212 nmol/ml) compared to the control group (2.24 ± 0.476 nmol/ml). In contrast, increasing body weight between groups did not show a significant difference.Conclusion: Exposure to PM 2.5 from peat biomass smoke increases oxidative stress in experimental animals.