MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Vol 10, No 1 (2023): February

Hematological Side Effects Management of Paclitaxel - Carboplatin Chemotherapy in Lung Cancer

Kornelis Aribowo (RSUP Dr. M. Djamil, Padang, West Sumatera, Indonesia)
Wiwi Monica Sari (RSUP Dr. M. Djamil, Padang, West Sumatera, Indonesia)



Article Info

Publish Date
30 Jul 2023

Abstract

Background:  Paclitaxel-carboplatin chemotherapy can cause hema-tological disorders. This regiment's hematological side effects include anemia, neutropenia, and thrombocytopenia. Data showed this regiment side effect occurs with grade iii/iv toxicity anemia, grade III/IV anemia by 41%, neutropenia (78%), and thrombocytopenia (41%). This hema-tological disorder occurs in bone marrow-producing areas due to chemotherapy. Each hematological disorder requires separate interven-tion.Case Presentation: A 54-year-old woman was diagnosed with a progressive disease of left lung adenocarcinoma (Exon 21 mutation) with TKI and received paclitaxel-carboplatin chemotherapy. The patient experienced side effects of anemia, neutropenia, and thrombocytopenia. Anemia was treated with PRC transfusion, neutropenia corrected with Filgrastim, and thrombocytopenia with platelet transfusion. Chemo-therapy was discontinued after five cycles because the Thrombo-cytopenia condition did not improve.Conclusion: Hematological parameters are essential in preparing for lung cancer chemotherapy. Uncorrectable hematological disorders lead to discontinuation of chemotherapy

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Journal Info

Abbrev

APKKM

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this ...