Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Vol 5, No 1 (2023)

Efek Ekstrak Etanol 70% Daun Kemangi Ocimum americanum L.) Terhadap Perbaikan Sel Spermatogenik Tikus Sprague-Dawley Jantan

Azrifitria Azrifitria (Unknown)
Eka Putri (UIN Syarif Hidayatullah Jakarta)



Article Info

Publish Date
08 Aug 2023

Abstract

Kemangi is a strong aromatic herb with aphrodisiac activity. The content of secondary metabolites that are antioxidants in kemangi are thought to be able to overcome fertility disorders due to the work of free radicals.  The aim of this study was to screen for phytochemicals and to analyze the activity of 70% ethanol extract of kemangi leaves (Ocimum americanum L.) on the repair of spermatogenic cells in male sprague-dawley rats exposed to lead. The results of phytochemical screening showed that the basil leaf extract was positive for alkaloids, flavonoids, tannins, and saponins. The results of administration of 70% ethanol extract of kemangi leaves at a dose of 50 mg/KgBW, 100 mg/KgBW, and 200 mg/KgBW in rats that had been induced by lead acetate increased the diameter of the seminiferous tubules, the number of pachytene cells, and round spermatid cells compared to the negative control but not significantly different (p > 0.05). The highest increase in all parameters of the spermatogenic cell repair test was given the kemangi leaves extract at a dose of 200 mg/KgBW.

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Journal Info

Abbrev

pbsj

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Description

Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short ...