SRIWIJAYA JOURNAL OF MEDICINE
Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023

The Role of Probiotics in The Prevention of Colorectal Cancer

Muhammad Ridho Mandiri (Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Wendy P (Department of Surgery, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Pariyana Pariyana (Department of Public Health, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)



Article Info

Publish Date
15 Jul 2023

Abstract

Colorectal cancer (CRC) is the most common malignant tumor of the colon and rectum in the gastrointestinal tract which is one of the major health problems in the world with the fourth leading cause of death in the world. Various sources state that the incidence of CRC is caused by an imbalance of intestinal micro flora. It is important to maintain a balance of live microorganisms in sufficient quantities to provide health benefits called probiotics. Probiotics can maintain intestinal integrity, regulate bowel movements, increase lactose intolerance, thereby boosting immunity and helping prevent overgrowth of harmful bacteria and fungal infections. Through non-specific physiological mechanisms and immunological mechanisms, probiotics have roles such as initiating antiproliferative responses and apoptosis of CRC cells, supporting the function of the intestinal mucosal barrier by producing mucus, inhibiting the enzymatic activity of pathogenic bacteria such as β-glucuronidase, β-glucosidase, azoreductase, and nitroreductase so as to prevent colorectal cancer. In addition, it is necessary to make a diet and regulate a good diet in order to create homeostasis of microorganisms, normal intestinal flora.  

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Journal Info

Abbrev

UnsriMedJ

Publisher

Subject

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Description

Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and ...