Synthesis of 4-Methoxybiphenyl Using Pd-Containing Catalysts Based on Polymeric Matrix of Functionalized Hypercrosslinked Polystyrene

Linda Nikoshvili (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Nadezhda Nemygina (Department of Physical Chemistry, Tver State University, Zhelyabova str., 33, Tver 170100)
Alexey Bykov (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Alexander Sidorov (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Valentina Matveeva (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Irina Tyamina (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Mikhail Sulman (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Esther Sulman (Department of Biotechnology and Chemistry, Tver Technical University, A.Nikitina str., 22, Tver 170026)
Barry Stein (Department of Biology, Indiana University, Bloomington, IN 47405)

Bulletin of Chemical Reaction Engineering & Catalysis
2015: BCREC Volume 10 Issue 3 Year 2015 (December 2015)

This paper describes synthesis of Pd-containing catalysts of Suzuki cross-coupling based on amino-functionalized hypercrosslinked polystyrene. The investigation of the influence of a palladium concen-tration, solvent composition, temperature, type and concentration of base, and a type of a gas phase was carried out. It was shown that the catalyst developed allows achieving conversion of 4-bromoanisole higher than 98% for less than 1 h at mild reaction conditions and in the absence of a phase transfer agent. Catalyst reduction was found to result in formation of small Pd nanoparticles (about 3 nm in diameter) and a large number of Pd clusters, which are highly active in Suzuki-Miyaura cross-coupling (conversion of 4-bromoanisole reached 90.2% for 3 h). Copyright © 2015 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).