Comparison of Cefoperazone + Sulbactam Versus Polymyxin B in the Management of Ventilator Associated Pneumonias Caused by Multi-Drug Resistant Acinetobacter

Fazal Rabbi (Intensive Care Unit Saidu Group of Teaching Hospital Swat, Pakistan)
Ajab Khan (Afridi Medical Complex and Teaching Hospital, Pakistan)
Syed Muhammad Muneeb Ali (Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan)
Syed Mujahid Gilani (Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan)
Taha Muhammad Usman Pasha (Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan)
Aqsa Ahmad (Premium International Hospital Islamabad, Pakistan)
Fazal Mustaan (Luqman International Hospital, Pakhtoon Khwa, Pakistan)
Tawseef Ahmad (Songkla University, Hat-Yai, Thailand)

International Journal of Applied and Scientific Research (IJASR)
Vol. 1 No. 2 (2023): October 2023

The present study entails a comparative analysis of the efficacy of polymyxin B and cefoperazone with sulbactam in the treatment of pneumonias induced by multidrug-resistant Acinetobacter strains. In the experimental group, the gender distribution was exactly the same (males: 21; females: 15). More co-morbidities exist in Group-II than in Group-I. In groups I and II, the mean ICU stays were respectively 11.86 days plus 2.06 SD and 11.47 days plus 1.61 SD. Day 2 post-therapy saw group mean CPIS at 7.781.48 and group-II at 7.081.23, respectively. The clinical response was seen in group-I (n=11/36) and group-II (n=24/36) patients in accordance with our operational criteria. Similar mortality rates applied to both groups. In line with our hypothesis, 31% (n=9/29) of group I survivors and 65.6% (n=21/32) of group II survivors both showed effectiveness (p=0.007).