Journal of Medicine and Health
Vol 6 No 1 (2024)

Prebiotic Effect of Cogon Grass Root Extract on Stimulating Lactic Acid Bacteria Growth in Mice Intestine

Gita W Pradini (Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran)
Nisa Fauziah (Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran)
Shinta Asarina (Microbiology Laboratory, Faculty of Medicine, Universitas Padjadjaran)
Neni Anggareni (Doctoral program in medical science, graduate school of comprehensive human science, University of Tsukuba)
Rini Widyastuti (Department of Veterinary Product, Faculty of Veterinary, Universitas Padjadjaran)
Mas Rizky AA Syamsunarno (Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran)



Article Info

Publish Date
28 Feb 2024

Abstract

Lactic acid bacteria (LAB) are known for their numerous beneficial effects for health and their colonization within intestines is affected by prebiotic consumption. Cogon grass root is an herbal medicine which contain substantial quantities of polyphenols. Recently, many studies suggested polyphenols as a novel group of prebiotics. Therefore, this study aimed to explore prebiotic effect of cogon grass root extract (CGRE) on stimulating growth of LAB in mice intestine. Mice (n =7/group) were divided into three groups; group A (control), group B and C received CGRE orally with daily dosage 90 and 115mg/kg BW, respectively. After 14 days of treatment, all mice were sacrificed. LAB was isolated and counted from ileum. Additional biochemical tests were performed to confirm the bacteria as LAB. Further identification of representatives LAB was performed with API-CHL-50 System. We found increased growth and diversity of LAB in the treatment group with optimum growth stimulation at CGRE dosage 90mg/KgBW daily (group B). Further identification showed Lactococcus lactis was the most frequent LAB found in all groups, with additional Lactobacillus paracasei and Lactobacillus curvatus were found in the treatment group. These findings support additional benefit of CGRE as prebiotics by stimulating LAB growth and diversity in mice intestine.

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Journal Info

Abbrev

jmh

Publisher

Subject

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Description

Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new ...