Postoperative surgical removal of large ameloblastoma tumours results in large mandibular defects that can affect the quality of life. This article reports prosthodontic aspects of rehabilitation in patients with rare giant ameloblastoma. After the surgical pro-cedure, prosthodontic treatment was performed by a prosthodontist. An 18-year-old male was referred to the prosthodontics clinic from an oral surgeon and the patient complained of difficulty chewing food due to the loss of almost all mandibular teeth after undergoing surgical removal of ameloblastoma. The patient received prosthodontic treatment with the use of obturators that rehabilitated the defect to improve his quality of life as it could help restore masticatory, speech, and aesthetic functions due to mandibular tooth loss. It was concluded that prosthodontic rehabilitation helped to improve the patient's quality of life.
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