<![CDATA[Bakteri Edwardsiella tarda yang menginfeksi ikan patin dapat menyebabkan kematian hingga 80%. Terong asam (Solanum ferox) mengandung senyawa antibakteri yang dapat menghambat pertumbuhan bakteri dan dapat membunuh bakteri penyebab infeksi. Tujuan penelitian adalah untuk mengetahui pengaruh ekstrak S. ferox terhadap respons imun ikan patin jambal (Pangasius djambal) serta memperoleh dosis optimum untuk penanggulangan bakteri E. tarda. Metode yang dilakukan adalah eksperimen dengan rancangan acak lengkap (RAL) dengan empat perlakuan dosis ekstrak terong asam (0, 300, 600, dan 900 ppm) serta kontrol (perendaman antibiotik komersial) dengan tiga ulangan. Ikan uji yang digunakan adalah ikan patin jambal berukuran 14-16 cm sebanyak 150 ekor. Perlakuan diberikan dengan perendaman ikan uji dalam larutan uji selama 7 hari. Parameter uji antara lain gejala klinis, total eritrosit, total leukosit, diferensial leukosit, aktivitas fagositosis, prevalensi, pertumbuhan bobot mutlak, dan kelangsungan hidup. Hasil penelitian menunjukkan bahwa perendaman ikan patin jambal dalam larutan ekstrak S. ferox meningkatkan respons imun ikan patin jambal yang terinfeksi E. tarda.. Hasil penelitian ini menyimpulkan bahwa ekstrak S. ferox dosis 600 ppm secara efektif meningkatkan aktifitas fagositosis yang kemudian mengoptimalkan respons imun dan profil darah ikan patin jambal. Infection of Edwardsiella tarda bacteria in farmed catfish could lead to mass mortality of up to 80% of the fish. Sour eggplant (Solanum ferox) contains antibacterial compounds which are capable of inhibiting the growth of bacteria and can kill infectious bacteria. The study aimed to determine the effect of S. ferox extract on the immune response of catfish (Pangasius djambal) and obtain its optimum dose to control the infection of E. tarda. The study used an experimental trial in which treatments were arranged in a completely randomized design (CRD) consisting of four treatment doses of sour eggplant extract (0, 300, 600, and 900 ppm) and control (immersion of commercial antibiotic) with three replicates. The test fish used were 150 catfish with a length of 14-16 cm. The treatments were applied by soaking the test fish in the test solutions for 7 days. The measured parameters included clinical symptoms, total erythrocytes, total leukocytes, leukocyte differential, phagocytic activity, prevalence, absolute weight growth, and survival. The results showed that the immersion of catfish in S. ferox extract solution increased the immune responses of catfish infected by E. tarda. The results of this study concluded that S. ferox extract at a dose of 600 ppm effectively increases phagocytic activity which then optimizes the immune response and blood profile of catfish.]]>
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