Breast cancer remains a health issue among women of reproductive age. There is breast self-examination (BSE) to prevent breast cancer. This study aimed to examine the effectiveness of health education using a leaflet about BSE. This study was supported by Senior high school number 2 Langowan. The study sample was 30 students from ages 14 to 16 years old in grades X and XI. The knowledge in this study was categorized as good and not. The result revealed increasing students with good knowledge from 73.3 to 90.0. Using paired t-tests this study revealed the effectiveness of health education using leaflets to improve BSE knowledge. There is a need for collaboration among stakeholders to emphasize this issue.
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