Differences in Effectiveness Test of Cream and Gel Preparations of Black Turmeric Rhizome Extract (Curcuma Caesia Roxb.) on Burn Wound Healing in White Rats (Rattus Norvegicus)

Udayani, Ni Nyoman Wahyu

Jurnal Aisyah : Jurnal Ilmu Kesehatan
Vol 9, No 2 (2024): September

Burns constitute a form of tissue damage and loss resulting from exposure to high-temperature sources, such as fire, hot water, chemicals, electricity, and radiation. Black turmeric (Curcuma caesia. Roxb) is identified as a natural remedy with empirical use for treating burns, owing to its composition of secondary metabolite compounds including alkaloids, flavonoids, and tannins. Topical formulations like creams and gels are commonly employed for burn treatment. This study focused on creating gel and cream formulations incorporating black turmeric extract at concentrations of 2%, 4%, and 8% to assess their effectiveness in burn wound healing. The objective was to investigate the impact of dosage forms on burn wound healing and identify the most efficacious preparation. Employing an experimental approach with a randomized pretest-posttest design involving a control group, the study comprised five test groups. Data analysis utilized the Kruskal-Wallis statistical test followed by post Mann-Whitney analysis. The results indicate that the dosage form significantly influences the healing of burns in white rats, with the gel containing 8% extract concentration identified as the most effective preparation.