This study aims to determine the effectiveness of using ChemCollective virtual laboratory media with guided inquiry learning models on student learning outcomes on acid-base titration material. The subjects of this study were XI MIA 1 and XI MIA 2 classes totaling 59 students. The research subjects were selected using saturated sampling technique. This research method is pre-experiment with one group pretest-posttest design. Data collection used tests in the form of pre-test and post-test and student response questionnaires which were then analyzed using the N-Gain test and effect size test. The results showed that the use of virtual laboratory media was effective for improving student learning outcomes with an N-Gain value of 0.5022 which was classified as moderate and the level of effectiveness was classified as very strong with an effect size value of 1.5716. Keywords: Effectiveness, Virtual Laboratory, Learning Outcomes, Acid-Base Titration
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