Jurnal Laot Ilmu Kelautan
Vol 6, No 1 (2024): Jurnal Laot Ilmu Kelautan

The Anticancer Potency of Pandanus odoratissimus Extracts In Human Breast Cancer (MCF-7) Cell Line

Andriani, Yosie (Unknown)
Yahya, Rodhiyah (Unknown)
Gazali, Mohamad (Unknown)
Amir, Hermansyah (Unknown)
Subhan, Beginer (Unknown)



Article Info

Publish Date
01 Apr 2024

Abstract

The development of novel chemical entities, novel pharmaceuticals, and novel drug leads frequently involves the use of natural sources. One of the most well-known plants, Pandanus odoratissimus (Pandanaceae), is native to Malaysia and has long been used in Ayurvedic medicine to treat a variety of illnesses. The purpose of this study is to determine P odoratissimus's antioxidant and anticancer properties against MCF-7 human breast cancer cell lines. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity was used to assess antioxidant activity, and among the other extracts, core exhibited the highest antioxidant value. An MTT assay was used to assess the effects of plant components on MCF-7 cell lines (3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide). The concentration of samples was shown to considerably boost the antioxidant activities in P. odoratissimus extracts. Our findings demonstrated that, after receiving treatment for 72 hours, sample treated cancer cells experienced a decline in cell viability. The IC50 value of 88.00 mg/ml indicates that the extracts have a poor cytotoxic impact and have no promise as anticancer agents against MCF-7, which is why it’s killing efficiency in cancer cells is regarded as lower.

Copyrights © 2024






Journal Info

Abbrev

JLIK

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences

Description

The scientific article, published in this journal covers a wide range of research topics in the field of marine biology, marine ecology, oceanography, marine acoustic, marine remote sensing,marine geographical information system (GIS), marine macrobiology, marine pollution, mariculture, marine ...