Fatigue is a condition that occurs after a strong and prolonged muscle contraction, where the muscle is no longer able to contract for a certain period of time. Activities that are too long can cause muscle fatigue. The purpose of this study was to determine the effect of watermelon exocarp extract on glucose and lactate levels in rats after swimming activity. This research method was carried out experimentally for 7 days; the data was analyzed using the paired t test method to find out the significant differences between groups I, II, and III. The results of this study indicate that blood sugar levels and blood lactic acid levels were measured before and after treatment. Data analysis using the Fairy test gave significant results if P was less than 0.05. The results of this study showed that administration of exocarp extract 500 mg per kg orally gave a significant effect. significant on blood glucose levels and lactic acid levels in rats. In conclusion, in this study, administration of watermelon exocarp extract (Citrullus lanatus (thunb)) had an effect on reducing blood glucose and lactate levels in rats, the fastest decreasing at a dose of exocarp extract at a dose of 500 mg/kg bw blood glucose was 72.75 while at a lactate level of 2.75 mmol/L.
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