<![CDATA[Background: A health information system (HIS) is one of the six fundamental elements or building blocks of a health system. In developing strategic policies, including internal efficiency (organization, management, and human resources), improving performance and competitiveness as a business entity without sacrificing the social mission it fulfills, and making fast and accurate decisions to improve services to society, computerized systems that process and combine all health service business process flows in the form of administrative, operational, reporting and coordination networks. Purpose: To analyze quality and utilization of sistem informasi karantina kesehatan (sinkarkes) using the HOT (Human, Organization, Technology) Fit Models approach. Method: This type of quantitative research was conducted at the Health Quarantine Center X, Palembang City in March-June 2024. The sample for this research was all 81 staff and 40 people from shipping agents who used the Health Quarantine Information System website (Syncarces). The independent variables are system quality, information quality, service quality and leadership support, while the dependent variables are system use, user satisfaction and user benefits. Research data comes from primary data sources and instruments in the form of questionnaires. Results: Data analysis shows that there is a significant relationship between system quality, information quality, service quality, leadership support, system users, and user satisfaction with the benefits of Sinkarkes users (p-value = <0.001). However, these variables do not have a normal distribution. Conclusion: There is an influence between system quality, information, services, leadership support, system use, and user satisfaction on the benefits of using health quarantine information.]]>
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