Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia

Abror Rahman (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Ifana Mahardika (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Ratih Dewi Saputri (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Tjitjik Srie Tjahjandarie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia)
Mulyadi Tanjung (Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia)

Jurnal Sains dan Kesehatan
Vol. 2 No. 4 (2020): J. Sains Kes.

Two quercetin derivatives, pachypodol (1) and ayanin (2) were isolated from the stem bark of Melicope quercifolia (B.S. William) Ridl. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antioxidant against DPPH radical showing their IC50 were 254 ± 10 and 38.55 ± 0.02 µg/mL, respectively.