Pengaruh Minyak Biji Jinten Hitam (Nigella sativa L) terhadap Kadar Interleukin-4 : Effect of Black Cumin Seed Oil (Nigella sativa L) on Interleukin-4 Level

Tantri Rachmayani (Universitas Ahmad Dahlan Yogyakarta)
Akrom Akrom (Universitas Ahmad Dahlan, Jl. Prof.DR. Soepomo Sh, Warungboto Yogyakarta, 55164, Indonesia)
Titiek Hidayati (Universitas Muhammadiyah Yogyakarta, Jl. Brawijaya, Geblagan, Tamantirto, Kasihan Bantul Yogyakarta 5518, Indonesia)

Jurnal Sains dan Kesehatan
Vol. 3 No. 6 (2021): J. Sains Kes.

Black cumin has a variety of efficacious substances, one of which is thymoquinon as an immunodulator, its role against Interleukin-4 with the subject of phase 2 clinical trials as an anti-inflammatory cytokine that is by inhibiting prostaglandin type E2 from arachidonic acid through induction resistance to cyclooxigenase-2. Aim to find out how the effect of Black Cumin Seed Oil in increasing levels of Interleukin-4. Randomized Clinical Trial study of 39 healthy participants of active smokers with the age of >18 years. Divided into 4 groups, namely Group 1 given placebo 3x1 capsules/day, group 2,3 and 4 given Black Cumin Seed Oil 3x1,3x2 and 3x3 capsules/day given for 30 days. Percentage il-4 using ELISA method. The results were analyzed using the One Way Annova method, with consecutive p-values (0.281 and 0.860) > 0.05 meaning there were meaningless differences between each treatment group. Based on the average percentage value of Interleukin-4, there was an increase in the MBJH treatment group of 3x1 capsules/day by 16,566% compared to the placebo group of 3x1 capsules/day by 13,995%.