Bioinformatic Analysis of Drug Candidate Compounds for Acquired Immunodeficiency Syndrome

Sukoco, Restu Megadiana
Fauzi, Ahmad
Nuha, Ulin

Proceeding International Conference on Global Resource Conservation
Vol 6, No 1: Proceeding of 6th ICGRC 2015

AIDS is a syndrome caused by HIV. The immune system of AIDS patient was too weak to fight off many infections. Many drugs developed to overcome these deadly disease. In this study, bioinformatic analysis performed on some drug candidate compounds that under development of FDA for AIDS’ patient. The drug candidate compounds are Amdoxovir, Alovudine, Elvucitabine, Dexelvucitabine, Capravirine, Darunavie, Calanolide-A, Tipranavir and Enfuvirtide. Molinspiration and preADMET web server has been used as tool for analyzing that drugs. As a results, our study revealed that not all of these drug candidate compounds fulfilled the Lipinski’s rule of five and toxicity test standart in silico.Keywords:Bioinformatic analysis; AIDS’ drug; Lipinski’s rule; toxicity test